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GPCRs Regulate Adenylyl Cylase Activity01:09

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Related Experiment Video

Updated: May 30, 2026

Sectioning Mammary Gland Whole Mounts for Lesion Identification
09:22

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Published on: July 24, 2017

Microglandular adenosis.

Dong-Ju Kim1, Woo-Young Sun, Dong-Hee Ryu

  • 1Department of Surgery, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju, Korea.

Journal of Breast Cancer
|August 18, 2011
PubMed
Summary

Microglandular adenosis (MGA) is a rare breast lesion often mistaken for cancer due to its appearance. Complete surgical excision is recommended for MGA diagnosed via core needle biopsy to rule out malignancy.

Keywords:
BreastCancerMicroglandular adenosis

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Area of Science:

  • Breast pathology
  • Oncology
  • Radiology

Background:

  • Microglandular adenosis (MGA) is a rare, benign breast lesion.
  • MGA can clinically mimic breast cancer due to its presentation as a palpable mass.
  • Histopathological differentiation from invasive carcinoma can be challenging due to the absence of a myoepithelial layer.

Observation:

  • A 72-year-old woman presented with a palpable right breast mass, fixed to surrounding tissues.
  • Mammography was inconclusive due to dense breast tissue (grade 4).
  • Ultrasonography showed a hypoechoic lesion with indistinct margins.

Findings:

  • Core needle biopsy diagnosed MGA.
  • Excision confirmed the MGA diagnosis.
  • The clinical presentation initially raised suspicion for breast cancer.

Implications:

  • Complete excision of MGA is crucial, rather than observation, due to its association with malignancy.
  • Accurate diagnosis of MGA is vital for appropriate patient management.
  • This case highlights the importance of surgical excision for breast masses suspicious for MGA.