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Updated: May 30, 2026
Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
Published on: September 4, 2011
Association of kisspeptin-10 levels with abortus imminens: a preliminary study
Serif Kavvasoglu1, Zehra Sema Ozkan, Banu Kumbak
1Department of Obstetric and Gynecology, Firat Universitesi Hastanesi Kadin Dogum Anabilim Dali, 23119 Elazig, Turkey.
Purpose:
To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome.
Methods:
A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups.
Results:
Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02).
Conclusion:
[corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.
