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Permeable cell models in stimulus-secretion coupling.

S J Hersey1, A Perez

  • 1Department of Physiology, Emory University, Atlanta, Georgia 30233.

Annual Review of Physiology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Selective cell membrane permeabilization using mechanical and chemical methods aids research into cell signaling. These techniques are valuable for studying stimulus-secretion coupling, phosphoinositide metabolism, and intracellular calcium regulation.

Area of Science:

  • Cell Biology
  • Biochemistry

Background:

  • Selective permeabilization of the plasma membrane is crucial for understanding cellular processes.
  • Mechanical and chemical methods offer ways to achieve this selective permeabilization.

Purpose of the Study:

  • To review the applications and significance of cell permeabilization techniques.
  • To highlight their contribution to understanding stimulus-secretion coupling and related signaling pathways.

Main Methods:

  • Discussion of various mechanical and chemical methods for selective cell membrane permeabilization.
  • Application of these methods across different cell types.

Main Results:

  • Permeabilization techniques have significantly advanced the understanding of phosphoinositide metabolism and intracellular calcium regulation.

Related Experiment Videos

  • These methods provide insights into cAMP-dependent pathways and enzyme activity in situ.

    • Conclusions:

    • Cell permeabilization techniques are highly useful for studying stimulus-secretion coupling and intracellular events.
    • The ease of these methods, especially chemical agents, suggests broad future applications in biological research.