Intramammary granular cell myoblastoma

Area of Science:

• Oncology
• Pathology
• Breast Surgery

Background:

• Intramammary granular cell myoblastoma is a rare breast neoplasm.
• It often presents in women aged 20-59, typically in the upper breast quadrants.
• Clinically, it can mimic fibroadenoma or breast cancer, posing diagnostic challenges.

Purpose of the Study:

• To report two cases of intramammary granular cell myoblastoma.
• To review the existing literature on this rare breast tumor.
• To analyze clinical presentation, diagnostic features, and treatment outcomes.

Main Methods:

• Case report of two female patients diagnosed with intramammary granular cell myoblastoma.
• Electron microscopy was utilized for detailed cellular analysis in one case.
• Literature review of 52 previously reported cases.

Main Results:

• Two female patients (15 and 21 years old) had no recurrence after 1 and 8.75 years post-surgery, respectively.
• Electron microscopy revealed characteristic eosinophilic granules but no definitive cell of origin.
• Review of 52 cases confirmed predilection for women aged 20-59 and upper breast quadrants.

Conclusions:

• Intramammary granular cell myoblastoma appears to be a benign neoplasm.
• Adequate surgical excision is associated with a favorable prognosis and no recurrence.
• Accurate diagnosis, distinguishing it from malignant lesions, is crucial.