[Space flight and modeling experiments: new approaches to evaluation and prophylaxis]

The article dwells on the general issues of orthostatic tolerance and new impedance methods of orthostatic test evaluation in spaceflight and simulated microgravity. The results imply that OT requires adequate body hydration and functioning of volume-regulating hormones. New pharmacological compensators of orthostatic intolerance were tested in modeling experiments. It was shown that desmopressin and water-salt supplements retain body liquid and electrolytes during bed rest and improve tolerance of the orthostatic test Therefore, simultaneous control of the hydration status and OT can be best provided through physiologically reasonable prescription of synthetic ADH analogs.