Related Experiment Video

Updated: May 30, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Development of a chemotherapy regimen interaction database for the mobile internet: detecting interactions with

Kevin Yi-Lwern Yap1, Wai Keung Chui, Alexandre Chan

  • 1Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.

Informatics for Health & Social Care
|August 19, 2011
PubMed
Abstract

Insights

Cancer patients face high risks of drug-drug interactions (DDIs). The OncoRx-MI mobile app helps clinicians manage these risks by detecting over 5000 DDIs between chemotherapy regimens and psychotropic drugs.

Area of Science:

  • Oncology
  • Pharmacology
  • Mobile Health

Background:

  • Cancer patients are highly susceptible to drug-drug interactions (DDIs).
  • Accurate DDI information is crucial for effective patient management.
  • Previous work established the OncoRx database for oncology prescriptions.

Purpose of the Study:

  • To develop a mobile application (OncoRx-MI) for detecting DDIs in cancer patients.
  • To leverage 3G networks for mobile internet access to the OncoRx database.

Main Methods:

  • Compiled data on anticancer drugs, chemotherapy regimens, and DDIs with psychotropics from diverse resources.
  • Developed the database and iPhone web documents using Adobe Dreamweaver CS4 and open-source scripts.

Main Results:

  • OncoRx-MI detects over 5000 DDIs (69.3% pharmacokinetic, 30.7% pharmacodynamic).
  • The application covers 256 chemotherapy regimens and 51 psychotropic drugs.
  • Information is presented in a user-friendly tabular format optimized for iPhone screens.

Conclusions:

  • OncoRx-MI is the first mobile DDI application capable of detecting interactions for combination chemotherapy regimens.
  • Future versions will expand to include DDIs with other drug classes.
  • Clinical usability studies are planned to assess the application's impact.

More Related Videos

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Related Concept Videos

Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue.
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...