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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

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Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

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Published on: May 17, 2024

Epigenetics and assisted reproductive technology.

A N Iliadou1, P C J Janson, S Cnattingius

  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. anastasia.iliadou@ki.se

Journal of Internal Medicine
|August 19, 2011
PubMed
Summary
This summary is machine-generated.

Assisted reproductive techniques (ARTs) may affect genomic imprinting, crucial for development. While animal studies show links to imprinting disorders, human data remain inconsistent, necessitating further research into epigenetics and ARTs.

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Area of Science:

  • Reproductive Biology
  • Epigenetics
  • Developmental Biology

Background:

  • Genomic imprinting involves erasure and re-establishment of methylation marks during germ cell development and early embryogenesis.
  • Assisted reproductive techniques (ARTs) introduce environmental stress to gametes and embryos.
  • Imprinting disorders are a concern in relation to ARTs due to potential epigenetic alterations.

Purpose of the Study:

  • To provide an overview of the field of epigenetics in relation to assisted reproductive techniques (ARTs).
  • To explore the putative link between ARTs and imprinting disorders.

Main Methods:

  • Literature review and synthesis of existing research on epigenetics, imprinting, and ARTs.
  • Analysis of data from animal studies and human clinical observations.

Main Results:

  • Animal studies suggest ARTs can alter methylation patterns, potentially leading to imprinting disorders.
  • Human data on the association between ARTs and imprinting disorders are currently inconsistent.

Conclusions:

  • The potential impact of ARTs on genomic imprinting requires further investigation, particularly in human studies.
  • Understanding epigenetic modifications in ARTs is crucial for assessing risks of imprinting disorders.