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Related Concept Videos

Narcolepsy01:07

Narcolepsy

Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...

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Related Experiment Video

Updated: May 30, 2026

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

Severe fatigue in narcolepsy with cataplexy.

Hal A Droogleever Fortuyn1, Rolf Fronczek, Mirjan Smitshoek

  • 1Department of Psychiatry, Radboud University Nijmegen Medical Center, The Netherlands. H.Droogleever-Fortuyn@psy.umcn.nl

Journal of Sleep Research
|August 19, 2011
PubMed
Summary

Narcolepsy patients frequently experience severe fatigue, distinct from excessive daytime sleepiness. This fatigue significantly impacts daily function, mental health, and overall quality of life.

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

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Last Updated: May 30, 2026

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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Published on: May 31, 2016

Area of Science:

  • Neurology
  • Sleep Medicine
  • Psychiatry

Background:

  • Excessive daytime sleepiness (EDS) is a primary narcolepsy symptom.
  • Fatigue is a common, yet distinct, complaint in narcolepsy patients.
  • Understanding fatigue's prevalence and impact is crucial for comprehensive narcolepsy care.

Purpose of the Study:

  • To determine the prevalence of severe fatigue in narcolepsy patients.
  • To investigate the relationship between severe fatigue and EDS, psychological distress, functional impairment, and quality of life.
  • To differentiate fatigue from EDS in narcolepsy.

Main Methods:

  • 80 patients with narcolepsy and cataplexy (ICSD-2 criteria) were assessed.
  • Fatigue was measured using the Checklist Individual Strength (CIS).
  • Psychological distress, functional impairment, and quality of life were evaluated.

Main Results:

  • 62.5% of patients reported severe fatigue (CIS score ≥ 35).
  • Severe fatigue was not correlated with EDS levels, confirming their distinction.
  • Fatigued patients exhibited greater functional impairment, depressive symptoms, and lower quality of life.

Conclusions:

  • A majority of narcolepsy patients experience severe fatigue, separate from EDS.
  • Severe fatigue significantly contributes to functional limitations and reduced quality of life in narcolepsy.
  • Targeting fatigue is essential for improving patient outcomes in narcolepsy management.