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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: May 30, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Microarray as a first genetic test in global developmental delay: a cost-effectiveness analysis.

Yannis Trakadis1, Michael Shevell

  • 1Department of Medical Genetics, McGill University, Montreal, Quebec, Canada.

Developmental Medicine and Child Neurology
|August 19, 2011
PubMed
Summary
This summary is machine-generated.

Array-based comparative genomic hybridization (aCGH) is more cost-effective than karyotyping for diagnosing global developmental delay (GDD), especially when performed locally. This genetic test offers a higher clinical yield for GDD evaluation.

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Published on: February 23, 2011

Area of Science:

  • Genetics
  • Clinical Diagnostics
  • Medical Technology

Background:

  • Global developmental delay (GDD) diagnosis traditionally relies on karyotyping.
  • Microarray technology, specifically array-based comparative genomic hybridization (aCGH), offers a higher clinical yield for GDD than karyotyping.
  • The widespread adoption of aCGH is hindered by the perception of higher costs compared to karyotyping.

Purpose of the Study:

  • To evaluate the cost-effectiveness of replacing karyotyping with aCGH as the initial diagnostic test for GDD.
  • To determine the impact of aCGH implementation on the total workup costs for GDD patients.

Main Methods:

  • Retrospective cost analysis of GDD workup in 114 children.
  • Comparison of costs between aCGH and karyotyping, considering both private and local laboratory settings.
  • Calculation of incremental cost per additional diagnosis for each method.

Main Results:

  • Using aCGH as a first test increased costs by $442 per individual with private labs but saved $106 with local labs.
  • The incremental cost per additional diagnosis was $12,874 for private aCGH versus under $1379 for local aCGH.
  • Local aCGH implementation demonstrated significant cost savings and diagnostic efficiency.

Conclusions:

  • Array-based comparative genomic hybridization (aCGH) is a cost-effective first-line genetic test for evaluating individuals with GDD.
  • Local implementation of aCGH technology can lead to substantial cost reductions in GDD diagnostics.
  • aCGH provides superior diagnostic yield and should be considered for routine GDD screening.