Decreased STAMP2 expression in association with visceral adipose tissue dysfunction
José María Moreno-Navarrete1, Francisco Ortega, Marta Serrano
1Service of Diabetes, Endocrinology, and Nutrition, Institut d'Investigació Biomèdica de Girona, CIBEROBN and Instituto de Salud Carlos III, 17007 Girona, Spain.
The Journal of Clinical Endocrinology and Metabolism
|August 19, 2011
Summary
Six-transmembrane protein of prostate 2 (STAMP2) expression decreases in visceral fat of obese individuals, particularly those with type 2 diabetes. Lower STAMP2 levels correlate with obesity and metabolic dysfunction, suggesting a role in visceral adipose tissue dysfunction.
Area of Science:
- Metabolic disease research
- Adipose tissue biology
- Inflammation and immunity
Background:
- Six-transmembrane protein of prostate 2 (STAMP2) is implicated as an inflammation and insulin resistance regulator in mice.
- Contradictory findings exist regarding STAMP2's role in human metabolic health.
Purpose of the Study:
- To investigate the association between STAMP2 and the inflammatory and metabolic status in human obesity.
- To explore STAMP2 expression in different adipose tissue depots and its correlation with obesity markers.
Main Methods:
- Analysis of STAMP2 gene expression in visceral and subcutaneous adipose tissue from 171 and 67 individuals, respectively.
- Studied STAMP2 expression during human preadipocyte differentiation.
- Treated human adipocytes with macrophage-conditioned medium, TNF-α, and rosiglitazone.
Main Results:
- STAMP2 gene expression was significantly reduced in visceral adipose tissue of obese subjects, especially those with type 2 diabetes.
- STAMP2 expression inversely correlated with obesity measures (BMI, waist, hip, fat mass) and metabolic disturbances (blood pressure, glucose).
- STAMP2 expression was higher in stromovascular cells than mature adipocytes and increased during differentiation, particularly in lean subjects.
Conclusions:
- Reduced STAMP2 expression (mRNA and protein) in visceral adipose tissue may indicate adipose dysfunction in obesity and type 2 diabetes.
- STAMP2's role in human metabolic health warrants further investigation, particularly in visceral fat.
