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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
Classification of Neurotransmitters01:30

Classification of Neurotransmitters

Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...

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Related Experiment Video

Updated: May 30, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

TrkB as a potential synaptic and behavioral tag.

Yuan Lu1, Yuanyuan Ji, Sundar Ganesan

  • 1Gene, Cognition and Psychosis Program, NIMH, National Institutes of Health, Bethesda, Maryland 20892-3714, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 19, 2011
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor receptor (TrkB) acts as a synaptic tag, capturing plasticity-related proteins essential for long-term memory consolidation. This discovery advances understanding of synapse-specific long-term memory formation.

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Related Experiment Videos

Last Updated: May 30, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

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Published on: September 4, 2015

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09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

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Conditional Genetic Transsynaptic Tracing in the Embryonic Mouse Brain
11:03

Conditional Genetic Transsynaptic Tracing in the Embryonic Mouse Brain

Published on: December 22, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cellular Biology

Background:

  • Long-term memory (LTM) requires new protein synthesis and synapse specificity.
  • Synaptic tagging is a proposed mechanism where activated synapses capture plasticity-related proteins (PRPs).

Purpose of the Study:

  • To investigate the role of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), as a potential synaptic tag.
  • To explore TrkB's involvement in synapse-specific long-term potentiation (L-LTP) and LTM consolidation.

Main Methods:

  • Examined TrkB activation by theta-burst stimulation (TBS) in relation to early-phase LTP (E-LTP) and L-LTP.
  • Used TrkB inhibition to assess its necessity for L-LTP induction and LTM consolidation.
  • Investigated behavioral consolidation of short-term memory (STM) into LTM under varying environmental conditions and TrkB inhibition.

Main Results:

  • TrkB activation by weak TBS was independent of protein synthesis and localized to stimulated synapses.
  • Strong stimulation-induced L-LTP in one pathway facilitated weak TBS-induced E-LTP to become L-LTP in an independent pathway.
  • TrkB inhibition blocked L-LTP and behavioral LTM consolidation, while sparing other pathways and STM.

Conclusions:

  • TrkB functions as a synaptic tag, mediating synapse-specific L-LTP and LTM.
  • TrkB signaling is crucial for capturing plasticity-related proteins and consolidating memories.
  • This finding provides a molecular basis for the synapse specificity of long-term memory.