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Munc13-1 is required for presynaptic long-term potentiation.

Ying Yang1, Nicole Calakos

  • 1Center for Translational Neuroscience, Department of Medicine/Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|August 19, 2011
PubMed
Summary

Presynaptic long-term potentiation (LTP) involves Munc13-1, crucial for vesicle priming. Its interaction with RIM1α is essential for sustained neurotransmitter release changes at hippocampal synapses.

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