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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes: Management and Pharmacotherapy01:15

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Related Experiment Video

Updated: Feb 6, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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[Diabetes and hemorheology].

J R Attali1, P Valensi

  • 1Service d'Endocrinologie, Diabétologie et Nutrition, Hôpital Jean-Verdier, Bondy.

Diabete & Metabolisme
|January 1, 1990
PubMed
Summary

Diabetes causes blood flow abnormalities, including increased viscosity and altered red blood cell function. These rheological changes in diabetic patients may worsen vascular complications and reduce tissue oxygenation.

Area of Science:

  • Hematology
  • Physiology
  • Pathophysiology

Context:

  • Diabetes mellitus is a complex metabolic disorder.
  • Associated vascular complications significantly impact patient morbidity and mortality.
  • Understanding rheological changes is crucial for managing diabetic complications.

Purpose:

  • To elucidate the rheological abnormalities associated with diabetes.
  • To explore the relationship between these abnormalities and vascular complications.
  • To identify potential mechanisms contributing to reduced tissue oxygenation in diabetics.

Summary:

  • Diabetes is linked to macrorheological issues like elevated blood and plasma viscosity.
  • Microrheological changes include altered erythrocyte deformability, increased aggregation, and adhesion.

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  • Leukocyte and platelet abnormalities also occur, potentially preceding other changes.
  • These rheological disturbances are pronounced in diabetics with angiopathy, impacting oxygen delivery and vascular health.

    • Impact:

    • Highlights the role of rheological dysfunction in diabetic vascular complications.
    • Suggests potential targets for therapeutic interventions to improve blood flow.
    • Underscores the need for further research into the precise mechanisms and the influence of hypertension.