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Interactions between endogenous and exogenous insulin and human pancreatic polypeptide secretion
R Zandomeneghi1, A Luciani, M Massari
1Istituto di Clinica Medica, University of Modena, Italy.
Diabete & Metabolisme
|January 1, 1990
Summary
Endogenous insulin secretion, measured by C-peptide (CPR), appears to inhibit human pancreatic polypeptide (hPP) release. This suggests a paracrine pathway influencing hormone regulation in healthy subjects.
Area of Science:
- Endocrinology
- Gastroenterology
Background:
- Human pancreatic polypeptide (hPP) plays a role in glucose homeostasis.
- The interplay between insulin secretion and hPP release requires further elucidation.
Purpose of the Study:
- To investigate the relationship between exogenous and endogenous insulin and plasma hPP levels.
- To explore the potential inhibitory effect of endogenous insulin on hPP secretion.
Main Methods:
- Three tests were conducted in 8 healthy subjects: intravenous tolbutamide injection, combined glucose-insulin infusion, and saline control infusion.
- Plasma glucose, C-peptide (CPR), and hPP levels were monitored over time.
Main Results:
- Tolbutamide injection initially increased CPR and decreased hPP, followed by decreased glucose and increased hPP.
- Glucose-insulin infusion led to increased plasma glucose and CPR, with a subsequent decrease in hPP.
- Early endogenous insulin secretion (CPR increase) correlated with decreased hPP levels.
Conclusions:
- Endogenous insulin secretion, indicated by CPR, may inhibit hPP release, potentially via a paracrine pathway.
- These findings contribute to understanding the complex hormonal regulation of glucose metabolism.