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Updated: May 30, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Immunosuppression in pediatric liver transplantation: are little people different?
1Paediatric Liver, GI, and Nutrition Centre, King's College Hospital, London, United Kingdom. anil.dhawan@kcl.ac.uk
Key Points:
1. Children differ from adults in the pharmacokinetics and dynamics of most immunosuppressive agents. 2. A lack of clinical trials continues to be an issue for newer agents. 3. On the basis of clinical case series, mycophenolate mofetil and sirolimus are increasingly being used as renal-sparing agents. 4. In comparison with adults, the recurrence of both viral hepatitis and hepatocellular carcinoma is less of an issue in children. 5. Particular attention should be paid to complete age-appropriate immunization to avoid vaccine-preventable diseases. 6. Paying special attention to adherence and the transition to adult services is essential for minimizing graft loss.
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