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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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[Understanding malaise occurring in elderly people].

Tristan Cudennec1, Julien Lagrandeur, Wassila Moussous

  • 1Service de Médecine Gériatrique, Hôpital Ambroise Paré (AP-HP), Boulogne.

Soins. Gerontologie
|August 20, 2011
PubMed
Summary

Malaise in older adults is a serious concern, accounting for 5-10% of hospital admissions in those over seventy. Cardiovascular and iatrogenic conditions are the most common causes, identifiable through clinical examination.

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Area of Science:

  • Geriatrics
  • Internal Medicine
  • Clinical Diagnostics

Context:

  • Malaise is a frequent presenting complaint in elderly patients.
  • It accounts for 5-10% of hospital admissions for individuals over 70.
  • Prompt evaluation is crucial due to potential serious underlying conditions.

Purpose:

  • To highlight the significance of malaise in the elderly population.
  • To identify common etiologies of malaise in geriatric patients.
  • To emphasize the diagnostic approach for elderly patients presenting with malaise.

Summary:

  • Malaise in elderly individuals warrants significant clinical attention.
  • Diagnostic workup, including clinical and additional examinations, is typically effective in identifying causes.
  • Cardiovascular diseases and iatrogenic pathologies are the most prevalent causes.

Impact:

  • Improved diagnostic strategies for malaise in geriatric populations.
  • Reduced morbidity and mortality associated with delayed diagnosis of serious conditions.
  • Enhanced understanding of common causes of hospitalization in the elderly.