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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 30, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Primary cutaneous lymphomas: a reprisal.

Alessandro Pileri1, Annalisa Patrizi, Claudio Agostinelli

  • 1Department of Internal Medicine, Geriatrics, and Nephrology, Division of Dermatology, University of Bologna, Bologna, Italy. alessandropileri@hotmail.it

Seminars in Diagnostic Pathology
|August 20, 2011
PubMed
Summary
This summary is machine-generated.

Primary cutaneous lymphomas (PCLs), including T-cell and B-cell types, are increasingly diagnosed. This study evaluates common PCL types, analyzing their clinical, histological, and molecular features for better prognosis and therapy.

Related Experiment Videos

Last Updated: May 30, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous lymphomas (PCLs) are diverse lymphoid neoplasms affecting the skin.
  • PCLs are categorized into cutaneous T-cell lymphomas (CTCLs) and cutaneous B-cell lymphomas (CBCLs).
  • An increasing incidence of PCLs has been observed over the past 30 years.

Purpose of the Study:

  • To evaluate the most common types of PCLs.
  • To analyze clinical characteristics, histology, phenotype, and molecular biology of PCLs.
  • To determine the prognosis and optimal therapy for common PCL subtypes.

Main Methods:

  • Review of clinical data for PCL patients.
  • Histopathological examination of skin biopsies.
  • Immunohistochemical and molecular analyses.
  • Prognostic factor assessment.
  • Therapeutic outcome evaluation.

Main Results:

  • Characterization of the most frequent PCL subtypes.
  • Identification of key clinical and histological features.
  • Correlation of phenotype and molecular markers with outcomes.
  • Assessment of treatment efficacy and patient survival.

Conclusions:

  • Understanding common PCL subtypes is crucial for accurate diagnosis and management.
  • Clinical, histological, and molecular features guide prognosis and therapeutic decisions.
  • Further research is needed to optimize PCL treatment strategies.