Related Experiment Video
Updated: May 30, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents
M Amarnath Reddy1, Nishant Jain, Deepthi Yada
1Inorganic and Physical Chemistry Division , Indian Institute of Chemical Technology (Council of Scientific and Industrial Research), Hyderabad 500607, India.
Abstract:
A new series of resveratrol analogues was designed, synthesized, and demonstrated to be tubulin polymerization inhibitors. Most of these compounds exhibited antiproliferative activity and inhibited in vitro tubulin polymerization effectively at concentrations of 4.4-68.1 and 17-62 μM, respectively. Flow cytometry studies showed that compounds 7c, 7e, and 7g arrested cells in the G2/M phase of the cell cycle. Immunocytochemistry revealed loss of intact microtubule structure in cells treated with 7c and 7e. Docking of compounds 7c and 7e with tubulin suggested that the A-ring of the compounds occupies the colchicine binding site of tubulin, which coordinates with Cys241, Leu242, Ala250, Val318, Val328, and I378, and that the nitrovinyl side chain forms two hydrogen bonds with the main loop of the β-chain at Asn249 and Ala250.
More Related Videos
07:20Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Antiviral Nucleoside Inhibitors
Drugs that Destabilize Microtubules
Drugs that Stabilize Microtubules
Inhibitors of Viral Protein Synthesis
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
2° Amines to N-Nitrosamines: Reaction with NaNO2