Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between analgesics and calcium channel blockers.

H F Miranda1, C Paeile

  • 1Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.

General Pharmacology
|January 1, 1990
PubMed
Summary

Calcium channel blockers demonstrate analgesic effects, potentially through calcium channel blockade. This suggests a link between these drugs and opioid mechanisms, offering new insights into pain relief.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Receptors involved in dexketoprofen analgesia in murine visceral pain.

Journal of biosciences·2020
Same author

Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.

Inflammopharmacology·2018
Same author

Erratum to: Antinociceptive interaction of gabapentin with minocycline in murine diabetic neuropathy.

Inflammopharmacology·2017
Same author

Antinociceptive interaction of gabapentin with minocycline in murine diabetic neuropathy.

Inflammopharmacology·2017
Same author

Antinociception induced by atorvastatin in different pain models.

Pharmacology, biochemistry, and behavior·2011
Same author

Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice.

Pharmacology, biochemistry, and behavior·2010

Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Management

Background:

  • Calcium channel blockers are a class of drugs.
  • Analgesic drugs are used to relieve pain.
  • Opioid drugs are potent pain relievers.

Purpose of the Study:

  • To review evidence on the analgesic effects of calcium channel blockers.
  • To explore the relationship between calcium channel blockade and antinociception.
  • To investigate the connection between calcium modulators and opioid drugs.

Main Methods:

  • Review of findings from diverse experimental models.
  • Biochemical and pharmacological experimental approaches.
  • Analysis of neuropharmacological hypotheses.

Related Experiment Videos

Main Results:

  • Calcium channel blockers and related drugs exhibit analgesic effects.
  • Antinociceptive actions of some analgesics may involve calcium channel blockade.
  • Evidence supports an interrelation between calcium modulators and opioid drugs.

Conclusions:

  • Calcium channel blockers possess significant analgesic properties.
  • The findings support a link between calcium channel modulation and opioid pathways.
  • A common binding site hypothesis may explain these interrelations.