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Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
Published on: June 21, 2024
Computed tomography-urography for upper urinary tract imaging: is it required for all patients who present with
Evelyne C C Cauberg1, C Y Nio, Jean M C H de la Rosette
1Department of Urology, Academic Medical Center, Amsterdam, the Netherlands. e.c.cauberg@amc.uva.nl
Insights
For microscopic hematuria, ultrasonography suffices to rule out upper urinary tract disease. Macroscopic hematuria warrants CT urography (CTU) due to a higher likelihood of detecting significant upper urinary tract (UUT) pathology.
Area of Science:
- Urology
- Radiology
- Diagnostic Imaging
Background:
- Hematuria, a common urological symptom, requires accurate diagnostic imaging to identify the source.
- Determining the appropriate imaging modality for upper urinary tract (UUT) evaluation is crucial for efficient patient management.
Purpose of the Study:
- To define patient criteria for utilizing computed tomography (CT) urography for upper urinary tract (UUT) imaging in cases of hematuria.
- To establish the diagnostic yield of CT urography (CTU) in patients presenting with microscopic or macroscopic hematuria.
Main Methods:
- Prospective study of 841 patients in a hematuria clinic (2006-2010).
- Standard hematuria workup followed by risk-factor-based selection for additional UUT imaging (ultrasonography or CT urography/MR urography).
- Analysis of predictive factors for cross-sectional urography findings.
Main Results:
- Cross-sectional urography identified relevant UUT lesions in 13.9% of patients.
- Ultrasonography results and hematuria type were significant predictors for CTU/MRU findings.
- CT urography/MR urography detected missed lesions in 9.6% of cases initially negative on ultrasonography, primarily stones.
Conclusions:
- Ultrasonography is adequate for excluding significant UUT disease in microscopic hematuria.
- CT urography is recommended as a first-line test for macroscopic hematuria due to increased detection rates of UUT disease.
Purpose:
To define in which patients who present with microscopic or macroscopic hematuria CT urography (CTU) is indicated as an imaging mode for the upper urinary tract (UUT).
Patients And Methods:
We conducted a prospective study on consecutive patients who attended a modern protocol-driven hematuria clinic from January 2006 to February 2010. Standard tests (history taking, physical examination, urinalysis via dipstick method, ultrasonography of kidneys and bladder performed by urologists, cystoscopy, and cytology) were directed to all patients, whereas the mode of additional UUT imaging (ultrasonography by a radiologist or four-phase CTU/magnetic resonance (MR) urography (MRU) when CTU was contraindicated) was selected according to a risk factor-based management algorithm. The added value of cross-sectional urography (CTU/MRU) supplementary to ultrasonography (by urologists) to detect renal masses, UUT tumors, and stones was assessed. Univariate and multivariate analysis on predictive factors for cross-sectional urography result were performed.
Results:
From the total of 841 patients, lesions that might account for hematuria could not be identified in 462 (54.9%), whereas in 250 (29.7%) and 124 (14.7%) patients, hematuria was from benign and malignant disease, respectively. Cross-sectional urography revealed relevant UUT lesions in 73 of 525 (13.9%) patients. Only result of ultrasonography (odds ratio [OR] 7.7, 95% confidence interval [CI] 4.0-14.9), P<0.001) and type of hematuria (OR 2.6, 95% CI 1.3-5.1, P=0.01) were significant predictors for cross-sectional urography result. In 44 of 456 (9.6%) patients with no abnormalities on ultrasonography, CTU/MRU revealed that these were false negatives, with most lesions missed being stones. In 253 of 309 (81.9%) patients with macroscopic hematuria, no lesions were detected in the UUT on CTU/MRU, in contrast to 199 of 216 patients (92.1%) with microscopic hematuria.
Conclusion:
For patients who present with microscopic hematuria, ultrasonography is sufficient to exclude significant UUT disease. For patients with macroscopic hematuria, the likelihood of finding UUT disease is higher, and a CTU as a first-line test seems justified.
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