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Evaluating the process parameters of the dry coating process using a 2(5-1) factorial design
Caroline Désirée Kablitz1, Nora Anne Urbanetz
1Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Context:
A recent development of coating technology is dry coating, where polymer powder and liquid plasticizer are layered on the cores without using organic solvents or water. Several studies evaluating the process were introduced in literature, however, little information about the critical process parameters (CPPs) is given.
Aim:
Aim of the study was the investigation and optimization of CPPs with respect to one of the critical quality attributes (CQAs), the coating efficiency of the dry coating process in a rotary fluid bed.
Materials And Methods:
Theophylline pellets were coated with hydroxypropyl methylcellulose acetate succinate as enteric film former and triethyl citrate and acetylated monoglyceride as plasticizer. A 2(5-1) design of experiments (DOEs) was created investigating five independent process parameters namely coating temperature, curing temperature, feeding/spraying rate, air flow and rotor speed. The results were evaluated by multilinear regression using the software Modde(®) 7.
Results And Discussion:
It is shown, that generally, low feeding/spraying rates and low rotor speeds increase coating efficiency. High coating temperatures enhance coating efficiency, whereas medium curing temperatures have been found to be optimum in terms of coating efficiency.
Conclusion:
This study provides a scientific base for the design of efficient dry coating processes with respect to coating efficiency.
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