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Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication

Jiri Bajgar1, Petr Hajek, Jiri Kassa

  • 1Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. bajgar@pmfhk.cz

Toxicology Mechanisms and Methods
|August 20, 2011
PubMed

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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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