Cholinergic control of male mating behavior in hamsters: effects of systemic agonist or antagonist treatment

Sexual behavior in male rats is thought to depend in part on central cholinergic activity. In particular, previous studies of responses to systemically administered cholinergic drugs suggest that male rat behavior can be facilitated by the muscarinic agonist oxotremorine but is disrupted by the muscarinic antagonist scopolamine. However, it is not clear how broadly these effects generalize across species. To address this issue, we observed the impact on sexual behavior in male hamsters of systemic treatment with oxotremorine or scopolamine. In each case, the peripheral muscarinic antagonist methylscopolamine was used as an auxiliary or control treatment to better isolate central cholinergic effects. Both oxotremorine and scopolamine disrupted male behavior in hamsters. For example, both increased the likelihood of failure to achieve intromission or ejaculation. Further, even on completed tests oxotremorine treatment led to changes including increases in mount latency and postejaculatory interval while scopolamine treatment caused changes including increases in ejaculation latency and intromission frequency. The many changes caused by these treatments suggest that acetylcholine helps to control many elements of male behavior, probably by acting at multiple brain sites. The generally similar responses to a cholinergic agonist and antagonist suggest the dependence of efficient mating behavior on optimal levels of central cholinergic activity.