Related Experiment Video
Updated: May 30, 2026

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms
J S Lindholt1, J L Martin-Ventura, S Urbonavicius
1Vascular Research Unit, Department of Vascular Surgery, Viborg Hospital, Viborg, Denmark. jes.s.lindholt@viborg.rm.dk
Objective:
The study aimed to test the potential role of insulin-like growth factor I (IGF-I) and IGF-II as biomarkers for abdominal aortic aneurysm (AAA).
Methods And Results:
IGF-I and II levels were analysed in 115 patients with screening diagnosed AAA kept under annual surveillance for 10 years. Serum IGF-I correlated positively with AAA size and growth rate (r = 0.23, P = 0.016 and r = 0.27, P = 0.004), persisting after adjustment for potential confounders. Serum IGF-I level predicted cases needing later surgery (AOC: 0.63; 95% confidence interval: 0.52-0.73).
Conclusions:
In this prospective, long-term study, baseline serum IGF-I correlated positively with AAA size and growth rate and predicted future need for preventive surgery.
Related Concept Videos
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm III: Interprofessional Care
Aneurysm I: Introduction