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Updated: May 30, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
Attending rounds: a patient with drug-resistant hypertension
1Department of Medicine, Renal Division, University of Pennsylvania, Philadelphia, PA 19104, USA. townsend@exchange.upenn.edu
Insights
Drug-resistant hypertension affects 12.5% of patients with high blood pressure (BP). This review offers a practical approach to managing this complex condition, blending clinical experience with current literature.
Area of Science:
- Cardiology
- Hypertension Management
Background:
- Drug-resistant hypertension (DRH) affects approximately 12.5% of individuals with high blood pressure.
- Managing DRH presents significant clinical and financial challenges in office-based settings.
Observation:
- Presents a case study of DRH, detailing the author's real-world experience.
- Integrates insights from the American Heart Association scientific statement on DRH.
Findings:
- Offers a logical and practical overview of DRH evaluation and management.
- Blends established literature with practical clinical experience.
Implications:
- Provides a useful framework for clinicians facing challenging hypertension cases.
- Aims to improve the management of difficult-to-treat high blood pressure.
Abstract:
Drug-resistant hypertension is present in about one in eight patients with high BP. It can be a frustrating and expensive condition to pursue from an office-based perspective. In this review, utilizing the American Heart Association scientific statement on drug-resistant hypertension as a guide, a case of drug-resistant hypertension is presented and walked through exactly as encountered by the author. Woven into the discussion is a combination of insights from the literature on this topic, blended with the experience of the author. This is not intended as an exhaustive review of each step in the evaluation and management process but, rather, as an overview incorporating a few carefully chosen references and, hopefully, a logical and useful approach to a common clinical challenge.
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