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An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
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Published on: June 8, 2021

Morphine use in cancer surgery.

Banafsheh Afsharimani1, Peter J Cabot, Marie-Odile Parat

  • 1School of Pharmacy, University of Queensland Brisbane, QLD, Australia.

Frontiers in Pharmacology
|August 20, 2011
PubMed
Summary
This summary is machine-generated.

Concerns exist regarding morphine

Keywords:
analgesiaanesthesiacancermorphineregionalsurgery

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Area of Science:

  • Anesthesiology and Oncology
  • Cancer Pain Management

Background:

  • Morphine is a cornerstone of perioperative pain management.
  • Concerns have arisen regarding morphine's potential impact on tumor recurrence and metastasis in cancer surgery.
  • Surgical stress and pain are known to promote cancer progression.

Purpose of the Study:

  • To evaluate the conflicting evidence on morphine's role in cancer surgery outcomes.
  • To assess the potential benefits of regional anesthesia/analgesia versus general anesthesia with opioid analgesia in cancer patients.
  • To explore the significance of analgesic strategies in managing cancer recurrence and spread.

Main Methods:

  • Review of retrospective clinical trials and prospective randomized trials.
  • Analysis of laboratory data investigating morphine's effect on cancer.
  • Comparison of outcomes between regional anesthesia/analgesia and general anesthesia/opioid analgesia groups.

Main Results:

  • Conflicting results from clinical trials regarding the benefits of regional anesthesia/analgesia.
  • Some studies suggest regional anesthesia may be beneficial, while others show no significant advantage.
  • Laboratory data on morphine's effect on cancer are contradictory, showing both tumor-promoting and anti-tumor effects.

Conclusions:

  • The impact of morphine on cancer recurrence and mortality remains unclear.
  • The optimal analgesic strategy for cancer surgery requires careful consideration.
  • Alternative analgesic regimens may be considered to mitigate potential adverse effects of morphine in cancer patients.