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Clinical experience with ciprofloxacin: analysis of a multicenter study
Indiana Medicine : the Journal of the Indiana State Medical Association
|April 1, 1990
Summary
Ciprofloxacin demonstrated high efficacy in treating various infections, achieving an 85.7% bacteriologic cure rate. Adverse reactions were infrequent, with only 1.5% of patients discontinuing therapy due to side effects.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Microbiology
Background:
- Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
- Bacterial infections pose a significant global health challenge.
- Assessing antibiotic efficacy and safety is crucial for treatment guidelines.
Purpose of the Study:
- To evaluate the clinical and bacteriologic efficacy of ciprofloxacin.
- To determine the incidence of adverse reactions associated with ciprofloxacin therapy.
- To assess ciprofloxacin's effectiveness in treating chronic infections.
Main Methods:
- A multicenter study involving 132 patients treated with ciprofloxacin.
- Microbiologic and clinical assessments were performed.
- Adverse events were systematically recorded and analyzed.
Main Results:
- High rates of bacteriologic cure (85.7%) and clinical cure (65.8%) were observed.
- Low rates of bacteriologic failure (2.9%) and clinical failure (7.9%) were reported.
- Adverse reactions were infrequent, leading to discontinuation in only 1.5% of patients.
Conclusions:
- Ciprofloxacin is an effective and generally well-tolerated antibiotic for various infections.
- The study supports the use of ciprofloxacin in both acute and chronic infectious conditions.
- Further research may explore ciprofloxacin's role in specific resistant bacterial strains.
