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Updated: May 30, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
One pot synthesis of cis-bispyrimidodiazepinone derivatives via low-valent titanium reagent (TiCl4/Sm)
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Abstract:
An efficient and convenient method for the preparation of cis-bispyrimidodiazepinone derivatives has been described. A variety of substrates can participate in the process with good yields, making this methodology suitable for library synthesis in drug discovery efforts. The mechanistic course of the reaction suggests the involvement of reduction, coupling which determine the products' configuration and cyclization by one-pot.
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