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Updated: May 30, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Palladium-catalyzed annulation reactions for diastereoselective cyclopentene synthesis
Benjamin L Kohn1, Elizabeth R Jarvo
1Department of Chemistry, Univerisity of California-Irvine, 1102 Natural Sciences II, Irvine, California 92697-2025, USA.
Abstract:
Palladium-catalyzed annulation reactions of conjugate acceptors and allenyl boronic ester provide substituted cyclopentenes in high yields and, where applicable, diastereoselectivities. This method provides rapid assembly of building blocks for natural product synthesis, including polycyclic lactone and lactam products. Reactions are hypothesized to initiate by conjugate addition of a nucleophilic propargylpalladium complex.
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