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Updated: May 30, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Is smoking a risk factor for collagenous colitis?

Lina Vigren¹, Klas Sjöberg, Cecilia Benoni

¹Division of Gastroenterology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden. lina.u.vigren@skane.se

Scandinavian Journal of Gastroenterology

|August 23, 2011

Summary

Smoking is a significant risk factor for collagenous colitis (CC), with smokers developing the condition over a decade earlier than non-smokers. This study highlights smoking as a key factor in CC onset and progression.

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Area of Science:

Gastroenterology
Epidemiology
Internal Medicine

Background:

Smoking's varied impact on inflammatory bowel diseases (IBD) is established, with Crohn's disease linked to smoking and ulcerative colitis to non-smoking.
Data regarding smoking habits in collagenous colitis (CC) remain scarce, necessitating further investigation.

Purpose of the Study:

To investigate smoking habits among patients diagnosed with collagenous colitis (CC).
To determine if smoking influences the clinical course and disease activity of CC.

Main Methods:

A cohort of 116 patients with CC (median age 62 years, 92% female) completed questionnaires on demographics, smoking status, and disease activity.
Smoking habits of CC patients were compared against data from the general Swedish population.

Main Results:

CC patients exhibited a significantly higher prevalence of smoking (37%) compared to controls (17%, p < 0.001).
Younger adults (16-44 years) with CC showed a markedly higher smoking rate (75%) versus controls (15%, p < 0.001).
Smokers were diagnosed with CC over a decade earlier (median age 42) than non-smokers (median age 56, p < 0.003), with all smokers having initiated before disease onset. No significant difference in active disease was observed, though smokers trended towards more active treatment (42% vs. 17%).

Conclusions:

Smoking is identified as a significant risk factor for developing collagenous colitis (CC).
Smokers are predisposed to an earlier onset of CC, typically more than 10 years prior to non-smokers.