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Related Experiment Videos

Clostridium perfringens corneal ulcer.

G A Stern, B L Hodes, E L Stock

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |April 1, 1979
    PubMed
    Summary

    Clostridium perfringens can cause serious corneal ulcers, especially in patients with Sjögren's syndrome. A distinctive bullous lesion was observed in both a human patient and experimental rabbit models of this infection.

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    Area of Science:

    • Ophthalmology
    • Microbiology
    • Infectious Diseases

    Background:

    • Sjögren's syndrome is an autoimmune disorder that can compromise ocular surface health.
    • Corneal ulcers are a serious complication that can lead to vision loss.
    • Clostridium perfringens is a bacterium known for causing gas gangrene and other infections.

    Observation:

    • A 76-year-old woman with Sjögren's syndrome developed a corneal ulcer.
    • The ulcer was caused by Clostridium perfringens.
    • Experimental keratitis was induced in rabbits using Clostridium perfringens.

    Findings:

    • Both the patient and experimental rabbits presented with a bullous lesion overlying the corneal ulcer.
    • This bullous lesion may be a characteristic sign of Clostridium perfringens keratitis.
    • Clostridium perfringens demonstrated opportunistic pathogenicity in the cornea.

    Implications:

    • Clostridium perfringens should be considered a potential opportunistic pathogen in bacterial corneal ulcers.
    • Anaerobic cultures are crucial for diagnosing suspected bacterial corneal ulcers.
    • Prompt identification and treatment are essential to prevent vision-threatening complications.

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