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Familial tumoral calcinosis in two Chinese patients: a case series
Che Zhang1, Jiaowei Gu, Xiaoli Cheng
1Taihe Hospital affiliated to Hubei Medical University, No, 32 South People's Road, Shiyan, Hubei Province, 442000, P,R,China. xiongkui@csco.org.cn.
Introduction:
Tumoral calcinosis is a rare and benign condition characterized by massive subcutaneous soft tissue deposits of calcium phosphate predominantly around large joints.
Case Presentation:
Familial tumoral calcinosis was present in two members of a Han Chinese family, namely, the son and daughter. The 14-year-old son had the first operation on his right sole of the foot at the age of six, and then experienced subsequent surgeries at a lesion in his right sole of the foot and left hip, respectively. The 16-year-old daughter underwent her first operation at the age of six in her left gluteal region, and subsequent surgeries were performed due to recurrence at the same lesion. Pathologic diagnoses of surgical specimens in both of the patients were reported as tumoral calcinosis. The laboratory results showed hyperphosphatemia with normal levels of serum calcium and alkaline phosphatase. Only surgical treatment was performed in both patients with satisfactory prognosis.
Conclusion:
This is the first report of Chinese familial tumoral calcinosis. The etiopathogenisis and treatment are discussed.
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