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Related Experiment Videos

Changes in cAMP concentrations during chronic cardiac hypertrophy.

D Stewart, D T Mason, J Wikman-Coffelt

    Basic Research in Cardiology
    |November 1, 1978
    PubMed
    Summary
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    Mild pulmonic stenosis in dogs causes significant right ventricular hypertrophy and increased myosin ATPase activity within 3 weeks. This condition also decreases oxygen levels and cAMP in the stressed right ventricle, but not the left.

    Area of Science:

    • Cardiovascular Science
    • Veterinary Cardiology
    • Cardiac Physiology

    Background:

    • Pulmonic stenosis is a common congenital heart defect in dogs.
    • Understanding the early cardiac adaptations to pressure overload is crucial for managing canine heart disease.

    Purpose of the Study:

    • To investigate the early effects of induced mild pulmonic stenosis on canine cardiac structure and function.
    • To analyze biochemical and contractile changes in the right ventricle following pressure overload.

    Main Methods:

    • Induction of mild pulmonic stenosis in dogs.
    • Measurement of right ventricular peak systolic pressure and free wall weight at sacrifice.
    • Assessment of tissue oxygen (PO2) and cyclic adenosine monophosphate (cAMP) concentrations.

    Related Experiment Videos

  • Evaluation of myosin ATPase activity and contractile element shortening velocity.

    • Main Results:

    • A 150% increase in right ventricular peak systolic pressure led to over 100% increase in right ventricular free wall weight by 3 weeks.
    • Hemodynamically stressed right ventricles showed decreased tissue PO2 and cAMP concentrations.
    • Myosin ATPase activity and contractile element shortening velocity were elevated in the stressed right ventricle.
    • The nonstressed left ventricle did not exhibit hypertrophy during the early postoperative period.

    Conclusions:

    • Early, mild pulmonic stenosis in dogs induces rapid and significant right ventricular hypertrophy.
    • Pressure overload alters myocardial metabolism and contractility, indicated by reduced PO2, cAMP, and increased myosin ATPase activity.
    • The left ventricle remains unaffected in the early stages of this induced condition.