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Au-nanocluster emission based glucose sensing.

A M P Hussain1, S N Sarangi, J A Kesarwani

  • 1Department of Physics, Cotton College, Guwahati, Assam 781001, India.

Biosensors & Bioelectronics
|August 23, 2011
PubMed
Summary
This summary is machine-generated.

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This study reports a novel glucose biosensor using gold (Au) cluster fluorescence quenching. The sensor accurately detects glucose in human serum, offering a rapid and sensitive diagnostic tool.

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Accurate glucose monitoring is crucial for diabetes management.
  • Existing glucose sensing methods may face limitations in sensitivity, specificity, or response time.

Purpose of the Study:

  • To develop a highly sensitive glucose biosensor utilizing the fluorescence quenching of gold (Au) clusters.
  • To validate the biosensor's performance in detecting β-d-glucose in human serum samples.

Main Methods:

  • Fabrication of l-cysteine capped Au cluster colloids.
  • Measurement of Au cluster fluorescence quenching in response to varying β-d-glucose concentrations.
  • Fourier Transformed Infrared Spectroscopy (FTIR) for interaction confirmation.
  • Assessment of interference from common biomolecules in serum.

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  • Validation using human serum samples from diabetic and non-diabetic individuals.

    • Main Results:

    • The glucose biosensor demonstrated high sensitivity to β-d-glucose within the 2.5–25.0 mM range.
    • A linear relationship was observed between Au cluster emission intensity and glucose concentration.
    • No significant interference was detected from ascorbic acid, uric acid, proteins, or peptides.
    • The biosensor's performance in human serum samples showed comparable or superior accuracy to hospital pathological data.
    • The sensor exhibits a rapid response time, on the order of nanoseconds to picoseconds, related to the emission lifetime of Au clusters.

    Conclusions:

    • The developed Au cluster-based biosensor is a sensitive, selective, and rapid tool for glucose detection.
    • Its practical utility is demonstrated by accurate glucose estimation in human serum, including diabetic samples.
    • This fluorescence quenching-based biosensor holds promise for improved diabetes diagnostics and monitoring.