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Splenic lymphoma with hypersplenism--a case report
S C Ng1, P Kuperan, P Jayalakshmi
1Department of Pathology, Medical Faculty University of Malaya, Kuala Lumpur.
Singapore Medical Journal
|February 1, 1990
Summary
A man with massive splenomegaly and hypersplenism remained undiagnosed for two years. Splenectomy led to a follicular lymphoma diagnosis and normalized blood counts.
Area of Science:
- Hematology
- Oncology
- Surgical Pathology
Background:
- Massive splenomegaly can cause hypersplenism, leading to pancytopenia.
- Undiagnosed splenomegaly poses risks of clinical deterioration and sepsis.
Observation:
- A 47-year-old male presented with hypersplenism and pancytopenia due to splenomegaly of unknown etiology.
- The patient experienced significant clinical decline and sepsis 18 months after initial presentation.
Findings:
- Splenectomy was performed for diagnosis and treatment.
- Histopathological analysis confirmed follicular lymphoma as the cause of splenomegaly and hypersplenism.
Implications:
- Early diagnosis and management of splenomegaly are crucial to prevent severe complications like sepsis.
- Splenectomy can be both a diagnostic tool and a therapeutic intervention for certain hematological conditions.
- Follicular lymphoma should be considered in the differential diagnosis of unexplained massive splenomegaly.