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Fragrance material review on 3-phenylpropyl cinnamate
S P Bhatia1, J Cocchiara, G A Wellington
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. sbhatia@rifm.org
Summary
This toxicologic and dermatologic review examines 3-phenylpropyl cinnamate, a fragrance ingredient. Data indicates it has low toxic potential, supporting its safe use in fragrances.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- 3-Phenylpropyl cinnamate belongs to the cinnamyl phenylpropyl compound group, characterized by aryl-substituted primary alcohols/aldehydes/esters.
- These compounds are simple aromatic molecules with saturated or unsaturated side chains and a primary oxygenated functional group, suggesting low inherent toxic potential.
Purpose of the Study:
- To conduct a comprehensive toxicologic and dermatologic review of 3-phenylpropyl cinnamate as a fragrance ingredient.
- To summarize available data on the physical properties, acute toxicity, skin irritation, and skin sensitization of 3-phenylpropyl cinnamate.
Main Methods:
- Literature review of existing toxicology and dermatology studies related to 3-phenylpropyl cinnamate.
- Evaluation and summarization of physical properties, acute toxicity, skin irritation, and skin sensitization data.
Main Results:
- 3-Phenylpropyl cinnamate exhibits low toxic potential.
- Available data on physical properties, acute toxicity, skin irritation, and skin sensitization were summarized.
Conclusions:
- 3-Phenylpropyl cinnamate is considered to have low toxic potential.
- Refer to Belsito et al. (2011) for a comprehensive safety assessment of this and related fragrance ingredients.
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