Related Experiment Video
Updated: Jan 31, 2026

Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
Study of early events during herpes simplex virus type 1 infection by confocal microscopy
1MRC-University of Glasgow, Centre for Virus Research, 8, Church Street, Glasgow G11 5JR, UK. roger.everett@glasgow.ac.uk
Abstract:
Laser scanning confocal microscopy is a powerful technique that can be applied to study the localisation and behaviour of proteins and nucleic acids in many experimental situations. It is a particularly useful technique for the study of virus infections because of the changes that occur in the distribution and amounts of both viral and cellular proteins as infection develops. These changes reflect key stages and important regulatory events that govern the efficiency of infection. Using herpes simplex virus type 1 infected cells as an experimental model, this article provides guidance for users new to confocal microscopy on basic principles and techniques. The emphasis is on recognising, diagnosing and avoiding potential artifacts, and the workflow of the production of high quality, technically correct images.
More Related Videos
Related Concept Videos
Integration of Synaptic Events
Confocal Fluorescence Microscopy
What are Viruses?
Types of Genetic Transfer Between Organisms
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Schwarzschild Radius and Event Horizon
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...

