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A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
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Intraocular pressure: modulation as treatment for glaucoma.

Joseph Caprioli1, Rohit Varma2

  • 1Jules Stein Eye Institute, The David Geffen School of Medicine, Los Angeles, California.

American Journal of Ophthalmology
|August 23, 2011
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Intervisit intraocular pressure (IOP) fluctuation is a significant risk factor for glaucoma progression, especially in patients with lower baseline IOPs and more advanced disease. Careful monitoring and aggressive treatment may be necessary for those with high-risk IOP variations.

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Last Updated: May 30, 2026

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08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Hypertension

Background:

  • Intraocular pressure (IOP) is a key factor in glaucoma management.
  • Intervisit IOP fluctuation has been investigated as a potential risk factor for glaucoma progression.
  • Understanding IOP dynamics is crucial for effective glaucoma treatment strategies.

Purpose of the Study:

  • To review the role of intervisit intraocular pressure (IOP) fluctuation as an independent risk factor for glaucoma.
  • To analyze existing literature on IOP variation and its association with glaucoma progression.
  • To synthesize findings from various studies to provide clinical insights.

Main Methods:

  • Literature review of pertinent publications in the peer-reviewed literature.
  • Analysis of disparate findings regarding the role of intervisit IOP variation.
  • Perspective synthesis of existing data.

Main Results:

  • IOP variation was a significant risk factor in studies with low IOPs and advanced glaucoma (e.g., AGIS).
  • IOP variation was not a significant risk factor in studies with higher IOPs and earlier stage glaucoma or ocular hypertension.
  • Findings suggest that the impact of IOP variation is dependent on patient characteristics, baseline IOP, and disease stage.

Conclusions:

  • Practitioners should consider reducing IOP variation in patients progressing at low mean IOP.
  • Single elevated IOP measures may indicate high risk for progressive glaucomatous damage.
  • Patients with concerning IOP variations require closer monitoring and potentially more aggressive treatment.