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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Patterned disorders in dermatology.

Ilan Goldberg¹, Eli Sprecher

¹Department of Dermatology, Tel-Aviv Sourasky Medical Center, 6 Weizmann St, Tel-Aviv 64239, Israel. ilangoldberg1@gmail.com

Clinics in Dermatology

|August 23, 2011

Summary

This summary is machine-generated.

Skin patterned disorders, including Blaschko lines, offer insights into genetic conditions. Studying acquired patterned lesions may reveal biologic foundations for common diseases.

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Area of Science:

Dermatology
Genetics
Pathophysiology

Background:

The skin provides a unique model for studying patterned disorders not apparent in other organ systems.
While Blaschko lines are well-recognized, other cutaneous patterned lesions have also been identified.
These disorders can be associated with both inherited and acquired diseases.

Purpose of the Study:

To review and discuss various types of cutaneous patterned disorders.
To explore the underlying pathophysiologic mechanisms, including somatic and X-chromosome mosaicism.
To highlight the potential of studying acquired patterned disorders for understanding common human diseases.

Main Methods:

Literature review of cutaneous patterned disorders.
Discussion of pathophysiologic mechanisms like somatic and X-chromosome mosaicism.
Analysis of associations between patterned lesions and inherited versus acquired diseases.

Main Results:

Several types of skin-patterned lesions exist beyond Blaschko lines.
Mechanisms such as somatic and X-chromosome mosaicism underlie these patterns.
Patterned lesions are observed in acquired diseases, suggesting underlying genetic defects.

Conclusions:

Cutaneous patterned disorders are diverse and linked to various genetic mechanisms.
The study of acquired patterned lesions is crucial for uncovering the pathogenesis of common human diseases.
Future research into these disorders may illuminate fundamental biologic processes.