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Updated: May 30, 2026

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Published on: June 16, 2020
Skin signs of systemic diseases
Dimitris Rigopoulos1, George Larios, Andreas Katsambas
1Department of Dermatology, University of Athens, Andreas Sygros Hospital, 5th Ionos Dragoumi St, 16121 Athens, Greece. drigop@hol.gr
Skin manifestations are crucial indicators of internal diseases, often presenting as early or sole symptoms. Recognizing these dermatologic signs aids physicians in diagnosing systemic conditions through direct clinical examination.
Area of Science:
- Dermatology and Internal Medicine
- Clinical Diagnostics
Background:
- The skin functions as a dynamic system interacting with the internal environment.
- Dermatologic signs frequently signal systemic diseases, sometimes being the initial or only manifestation.
- Skin lesions can serve as invaluable markers for diagnosing internal disorders.
Purpose of the Study:
- To review and describe the skin signs associated with various systemic diseases.
- To highlight the diagnostic utility of dermatologic manifestations in internal medicine.
Main Methods:
- Review of clinical features of skin lesions in systemic diseases.
- Emphasis on direct clinical examination as a diagnostic tool.
Main Results:
- Skin manifestations are common and critical indicators of underlying systemic conditions.
- The skin's immediate accessibility allows for early detection of internal diseases.
- Dermatologic signs provide essential diagnostic clues for physicians.
Conclusions:
- The skin is a vital diagnostic window into systemic health.
- Understanding skin signs of systemic diseases is crucial for general physicians, internists, and dermatologists.
- Direct clinical examination of the skin remains a fundamental diagnostic approach.
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