Related Experiment Video
Updated: May 30, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
Risk factors for eclampsia: a population-based study in Washington State, 1987-2007
Anna E Coghill1, Susanne Hansen, Alyson J Littman
1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. acoghill@fhcrc.org
American Journal of Obstetrics and Gynecology
|August 23, 2011
Summary
Previously identified risk factors for eclampsia remain relevant in contemporary populations. Factors like nulliparity, young or advanced maternal age, and certain medical conditions increase risk, while multiparity and smoking decrease it.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Epidemiology
- Maternal Health
Background:
- Eclampsia is a severe complication of pregnancy.
- Understanding contemporary risk factors is crucial for prevention and management.
- Previous studies identified several risk factors, but their relevance in current populations needed investigation.
Purpose of the Study:
- To investigate the association between previously identified risk factors and eclampsia.
- To examine these associations in a contemporary, diverse cohort of women.
Main Methods:
- Population-based case-control study using birth certificate and hospital discharge records (1987-2007).
- Involved women giving birth to singletons in Washington State.
- Multivariable logistic regression and multiple imputation were used to analyze data.
Main Results:
- Nulliparous women had a greater risk of eclampsia compared to parous women.
- Young maternal age (<20 years) and advanced maternal age (≥35 years) were associated with increased risk.
- Gestational diabetes, prepregnancy obesity, low socioeconomic status, and abnormal weight gain during pregnancy were positively associated with eclampsia risk. Multiparity and smoking showed an inverse association.
Conclusions:
- Established risk factors for eclampsia continue to be associated with the condition in current birth cohorts.
- These findings highlight the persistent importance of monitoring and addressing these risk factors.
- Further research may focus on interventions targeting these identified risk factors.
Related Concept Videos
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:24Epilepsy and Seizures: Overview
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...