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Bone marrow stem cells repopulate thyroid in X-ray regeneration in mice
V M Mikhailov1, A V Sokolova, V B Serikov
1Institute of Cytology, Russian Academy of Sciences, Russia.
Summary
Bone marrow stem cells aid thyroid regeneration after radiation exposure. These cells contribute to thyroid tissue repair, as shown by tracking green fluorescent protein (GFP)-positive cells in irradiated mice.
Area of Science:
- Endocrinology
- Stem Cell Biology
- Radiation Biology
Background:
- Thyroid gland regeneration mechanisms after radiation injury are not fully understood.
- Investigating cellular contributions to thyroid repair is crucial for understanding radiation effects.
Purpose of the Study:
- To clarify thyroid regeneration mechanisms in mice post-X-ray exposure.
- To identify the role of bone marrow stem cells in thyroid repair.
Main Methods:
- Utilized chimeric mice with green fluorescent protein (GFP)-positive bone marrow.
- Employed morphological and immunocytochemical techniques to track GFP-positive cells in thyroid tissue.
- Analyzed cell distribution using confocal microscopy and co-localization studies.
Main Results:
- GFP-positive cells were found in thyroid follicle walls, between follicles, and within the colloid.
- A significant percentage of GFP-positive cells co-localized with thyroglobulin.
- Bone marrow cells constituted a substantial portion of GFP-positive blood and bone marrow cells.
Conclusions:
- Bone marrow stem cells actively participate in thyroid gland regeneration following 5Gy X-ray exposure.
- The study provides evidence for stem cell-mediated thyroid tissue repair after irradiation.
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