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Related Experiment Video

Updated: May 30, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

The relation between depression and parkin genotype: the CORE-PD study.

A Srivastava¹, M-X Tang, H Mejia-Santana

¹Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Parkinsonism & Related Disorders

|August 23, 2011

Summary

Parkin mutations are linked to early onset Parkinson's disease (EOPD). Compound heterozygous parkin mutations in unaffected relatives may increase depression risk, suggesting a broader role for parkin in non-motor symptoms.

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Last Updated: May 30, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Area of Science:

Neurogenetics
Psychiatry
Movement Disorders

Background:

Parkin mutations are a known genetic risk factor for early onset Parkinson's disease (EOPD).
The role of parkin mutations in non-motor manifestations, such as depression, is not well understood.
Genetic factors contributing to depression require further characterization.

Purpose of the Study:

To investigate the association between parkin mutations and depression in individuals with EOPD and their relatives.
To explore the phenotypic spectrum of parkin mutations, including non-motor symptoms.

Main Methods:

Psychiatric information was collected using the Patient Health Questionnaire and Beck Depression Inventory II.
328 genotyped individuals were analyzed, including 88 probands with EOPD (41 with parkin mutations, 47 without) and 240 unaffected relatives.
Statistical analysis was performed to assess the risk of depression associated with parkin mutations.

Main Results:

No association between parkin genotype and depression risk was found among EOPD probands.
Among unaffected relatives, compound heterozygotes for parkin mutations showed a significantly increased risk of depressed mood and moderate to severe depression.
Increased Beck Depression Inventory II scores were observed in relatives with compound heterozygous parkin mutations compared to those without.

Conclusions:

Relatives of EOPD cases with compound heterozygous parkin mutations may have an elevated risk of depression.
These findings suggest a potential genetic contribution of parkin mutations to depression.
Parkin mutations may contribute to non-motor manifestations that precede the clinical onset of Parkinson's disease.