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Updated: May 30, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Skin: histology and physiology of wound healing
Eric A Gantwerker1, David B Hom
1Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0528, USA. david.hom@uc.edu
Abstract:
It is important to understand the histology and physiology of skin for the prediction and optimization of wound healing. Optimal postoperative wound healing to minimize scarring entails minimizing local, systemic, and environmental factors that lead to poor wound healing. Keeping the wound clean and moist, minimizing trauma, and infection are the local wound tenets. Systemic tenets include minimizing medications that inhibit processes of wound healing, maintaining adequate nutrition, pain palliation, UV protection, and smoking cessation. This article presents the dynamic process of wound healing and the basic tenets to minimize scarring.
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