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P50 variations in Behcet`s patients without neurologic findings
Meral Ascioglu1, Mustafa Arslan, Cem Suer
1Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
Neurosciences (Riyadh, Saudi Arabia)
|August 23, 2011
Summary
Behcet`s patients show reduced P50 auditory response suppression, indicating subclinical central nervous system deficits. This neurophysiological marker aids in detecting early neurological involvement in Behcet`s disease.
Area of Science:
- Neuroscience
- Clinical Neurophysiology
Background:
- Behcet`s disease is a multisystem inflammatory disorder.
- Neurological manifestations can occur but may be preceded by subclinical changes.
Purpose of the Study:
- To investigate subclinical lesion involvement in Behcet`s patients using the P50 auditory evoked potential.
- To assess potential neurophysiological markers for early detection of central nervous system involvement.
Main Methods:
- Auditory evoked potentials (P50 component) were recorded in 18 Behcet`s patients without neurological symptoms and 18 controls.
- Standard EEG electrodes and a paired auditory stimuli paradigm were employed.
- P50 wave amplitudes and latencies were measured using a computer system.
Main Results:
- Behcet`s patients exhibited significantly decreased suppression of P50 responses compared to healthy controls.
- This finding suggests an impaired ability to filter repeated sensory information.
Conclusions:
- Reduced P50 response suppression in Behcet`s patients indicates a deficit in central nervous system functions like attention and sensory processing.
- The P50 component can serve as a valuable neurophysiological marker for subclinical lesions in Behcet`s disease.
