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Updated: May 30, 2026

Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications
Published on: May 8, 2026
Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO₂)
Haifeng Bao1, Jianping Yang, Yan Huang
1College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang 310036, P. R. China.
Abstract:
We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core-shell nanostructures (LDH@mSiO(2)) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N(2) sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m(2) g(-1)), and large pore volume (∼0.22 cm(3) g(-1)). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO(2) core-shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.
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