Influenza drug resistance.
Andrés Pizzorno1, Yacine Abed, Guy Boivin
1Research Center in Infectious Diseases, Centre hospitalier Univeritaire de Quebec and Laval University, Québec City, Québec, Canada.
Seminars in Respiratory and Critical Care Medicine
|August 23, 2011
Summary
Antiviral drugs are crucial for managing influenza, but resistance is a growing concern. Continuous monitoring and new drug development are essential for effective influenza control.
Area of Science:
- Virology
- Infectious Diseases
- Pharmacology
Background:
- Influenza viruses cause significant global mortality and societal impact.
- Antiviral drugs are vital for influenza control due to vaccine limitations.
- Approved antivirals include adamantanes and neuraminidase inhibitors (NAIs).
Purpose of the Study:
- To highlight the importance of antiviral drugs in influenza management.
- To address the challenge of emerging drug-resistant influenza strains.
- To emphasize the need for ongoing resistance monitoring and new therapeutic strategies.
Main Methods:
- Review of current anti-influenza drug classes and their clinical use.
- Analysis of documented cases of antiviral resistance in influenza viruses.
- Discussion of the implications of drug resistance on treatment efficacy.
Main Results:
- Adamantane resistance is widespread, limiting their clinical utility.
- Neuraminidase inhibitors (NAIs) are effective but face emerging resistance, exemplified by oseltamivir-resistant H1N1 strains.
- Drug-resistant influenza variants pose a significant threat to public health interventions.
Conclusions:
- The emergence of drug-resistant influenza strains necessitates continuous monitoring of resistance markers.
- Development of novel anti-influenza drugs and combination therapies is crucial.
- Sustained efforts are required to maintain effective influenza treatment options.
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