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Updated: May 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Rationale for complete metastasectomy in patients with stage IV metastatic melanoma
David W Ollila1, Ana L Gleisner, Eddy C Hsueh
1Division of Surgical Oncology and Endocrine Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA. david_ollila@med.unc.edu
Abstract:
Patients with stage IV melanoma have usually been treated with systemic therapies; however, the overall survival for patients with this approach is disappointing. A complete surgical resection of metastatic disease to stage IV sites offers the best chance to maximize survival. This review article will present data supporting the position that if a complete metastasectomy is technically feasible, then surgery should be strongly considered the first option for properly selected patients with stage IV melanoma.
