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In vivo viscoelastic behavior in the human aorta
1Department of Cardiovascular Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
Circulation Research
|May 1, 1990
Summary
This study measured human aorta viscoelasticity in vivo, finding aortic wall viscosity is similar to in vitro conditions. This research provides insights into the aorta's mechanical properties.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Medical Physics
Background:
- The human aorta's viscoelastic properties are crucial for cardiovascular health.
- Understanding in vivo mechanical behavior is essential for diagnosing and treating aortic diseases.
Purpose of the Study:
- To characterize the in vivo viscoelastic properties of the human abdominal aorta.
- To compare in vivo and in vitro aortic wall viscosity.
Main Methods:
- Noninvasive ultrasonic displacement meter for aortic diameter measurement.
- Catheter tip micromanometer for intra-aortic pressure measurement.
- Frequency analysis to determine pressure-strain modulus (Ep) and phase lag.
Main Results:
- The pressure-strain modulus (Ep) was (1.52 +/- 0.57) x 10^6 dyne/cm^2 at the fundamental frequency (1.2 Hz).
- Phase lag at the fundamental frequency was -6.7 +/- 2.1 degrees, consistent with in vitro data.
- A model separating elasticity and viscosity confirmed aortic wall viscosity is similar in vivo and in vitro.
Conclusions:
- Human aortic wall viscosity in vivo is comparable to in vitro measurements.
- The study successfully characterized in vivo viscoelasticity, accounting for nonlinear pressure-diameter relationships.
- Findings contribute to a better understanding of aortic biomechanics.