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Updated: May 30, 2026

Lentivirus Production
Published on: October 2, 2009
Drug discovery for neglected tropical diseases at the Sandler Center
Stephanie A Robertson1, Adam R Renslo
1Sandler Center for Drug Discovery, Department of Pharmaceutical Chemistry, University of California, 600 16th Street, S-272, San Francisco, CA 94158, USA. stephanie.robertson@ucsf.edu
Abstract:
The Sandler Center's approach to target-based drug discovery for neglected tropical diseases is to focus on parasite targets that are homologous to human targets being actively investigated in the pharmaceutical industry. In this way we attempt to use both the know-how and actual chemical matter from other drug-development efforts to jump start the discovery process for neglected tropical diseases. Our approach is akin to drug repurposing, except that we seek to repurpose leads rather than drugs. Medicinal chemistry can then be applied to optimize the leads specifically for the desired antiparasitic indication.
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